A couple with normal phenotype, the woman was 26 years old and the man was 27 years old, and the woman did not pregnant for 2 years after marriage. The woman has been delayed menstrual cycles since 20 and her menstrual period is three months long. The couple’s karyotype analysis was normal, and the patient couples have no family history of abnormal pregnancy. Doctors suggested the couple to undergo infertility gene test in order to find out the genetic cause of her disease. The test results showed that the woman carried a c.631C>T heterozygous mutation in the BMP15 gene, which was confirmed by Sanger sequencing. The pedigree verification analysis showed that the mutation was inherited from her father who was a carrier of hemizygous mutation. The man did not carry the relevant gene mutation. BMP15 mutation can lead to premature ovarian failure, which is an X-linked dominant inheritance. Because such patients will quickly enter the state of premature ovarian failure after the age of 30, so early marriage and early childbearing should be recommended. Considering the situation of the couple, the doctor suggested that the patient could conceive healthy babies with the aid of assisted reproductive technology, and in order to avoid uterine atrophy after menstruation failure, she was recommended to take CLIMEN, and receive conventional gynecological examination as well as liver and kidney function check every half year. Finally, the couple had successfully given birth to a healthy baby through PGS technology.