A couple had been married for 2 years and still not pregnant. The doctor suggested that a routine examination should be performed first. The results showed that the man had severe oligozoospermia. In order to further clarify the cause, the man undergoes a Y chromosome microdeletion test. After comprehensive consideration, the doctor suggested that the patient obtains sperm by TESE and conceive children through PGS technology. Finally, the couple had successfully given birth to a healthy baby girl.